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Dataset

adaptyv-bio/EGFR_binders-v1

This dataset includes binding protein designs targeting the Epidermal growth factor receptor(EGFR), a drug target associated with various diseases.

Created on: October 25, 2024Dataset size: 66 KBNumber of datapoints: 213
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Tags

protein-design

Modalities

No modalities found.

Details

README

Background

Target details

Epidermal Growth Factor Receptor (EGFR) is a transmembrane protein that plays a critical role in cell growth, differentiation, and survival. It is frequently overexpressed or mutated in various cancers, including non-small cell lung cancer, colorectal cancer, and head and neck cancer. This makes EGFR a crucial target for cancer therapies such as Cetuximab, an antibody with more than 1B USD in annual revenue.

  • Target Protein: EGFR
  • Organism: HUMAN
  • Uniprot Accession ID: P00533
  • Protein sequence: LEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPS
  • Structure PDB: 6ARU

64ru

Binding protein designs

This dataset contains 202 designed EGFR-binding protein sequences, along with experimental binding affinity results tested by the AdaptyvBio team, plus 11 additional sequences ordered by Anthony Gitter and tested by the AdaptyvBio team.

Updates

Compared to version v0, the two weak binders which were classified as binders are now classified as non-binders in v1 due to their relatively weak interactions, which may not be stable or effective in inhibiting EGFR. The names of weak binders are "alecl-Sequence1" and "alan.blakely-design:5 n:6|mpnn:1.247|plddt:0.825|ptm:0.709|pae:10.151|rmsd:3.535".

Reference: